Led by fourth year coach Ray McCallum, the Titans played their home games at Calihan Hall as members of the Horizon League.

Despite 15 points from Doug Anderson, and 11 rebounds from Eli Holman, Kansas cruised to a 65–50 victory, ending the Titans season.

Ray McCallum shot 8–of–10 on the night and lead Detroit in scoring with 24 points, adding three steals and five rebounds.

Lake Erie held Detroit scoreless for the first four minutes of the game, going up 6–0 before Nick Minnerath hit a three-pointer, his first points of 19 tallied in the half.

However, poor shooting plagued Detroit, as Notre Dame held the Titans without a field goal for almost 8 minutes, going on a 14–0 run to take a six–point lead.

Detroit held Notre Dame at bay with its defense, but in the end could not overcome its shooting woes, losing to the Fighting Irish 59–53.

Nick Minnerath took a charge early from a Bowling Green player, resulting in a knee injury that left him in the locker room for the remainder of the game.

[13][14] It was later revealed that the charge tore his MCL, putting him out for the entire season and leaving Detroit with just eight remaining eligible players.

The Titans had a few bursts of offense to start the second half, gaining two separate 5-point leads, but the undermanned roster couldn't overcome shooting woes and the loss of Minnerath, falling 67–61 to the Falcons.

Heavily undermanned with Eli Holman and Chris Blake still suspended and Nick Minnerath lost to an injury suffered the night before against Bowling Green State, Titans players Evan Bruinsma, Doug Anderson, and LaMarcus Lowe have been left to rise to the occasion.

Anderson, Jason Calliste, and Chase Simon hit three-pointers in the first few minutes to give Detroit an early 16–8 lead.

On the inbound pass, Donovan Foster stripped the ball and gave it to Ray McCallum for the layup as time expired, bringing the Penguin lead down to just one at 35–34.

Cleveland State stretched the lead back to 7 with 25 seconds remaining, and the Titans lost in the effort 66–61, falling to 3–6 on the season and 0–2 in conference play.

Doug Anderson led the team in scoring for the first time this season, putting up 17 points on 5–of–7 shooting and 7–of–7 from the free throw line.

[22][23] 12/5/2011 – Detroit vs St. John's In commemoration of the hall–of–fame announcer and former head coach, the Detroit Titans unveiled "Dick Vitale Court" during a dedication ceremony prior to the night's game against the St. John's Red Storm in front of a packed crowd of 5,377, more than tripling Callihan Hall's average on the season.

The Red Storm led a furious comeback to start the second half, going on a 9–0 run to bring the Titan lead down to just a single bucket, but a jump shot from Chase Simon followed by a fast–break by Doug Anderson helped regain the momentum.

St. John's attempted to mount several runs, but each time the Titans would answer, never letting the Red Storm be down just a single possession in the final 7:30 of the game.

This was the first game of the season where the Titans had 10 active players, just in time to travel to Tuscaloosa to face the nationally ranked Alabama Crimson Tide.

The Bulldogs would stretch their lead to 15 with 15:05 remaining in the game before the Titans mounted another run fueled by a dunk and tip–in from Eli Holman.

With the Titans down by a basket with 19 seconds to play, Holman went for a layup but was blocked by State player Arnett Moultrie.

Early in the second half up just 48–43, Eli Holman had a slam dunk and Doug Anderson followed it up with two more, permanently shifting the momentum in favor of the Titans.

UIC jumped out to a 16–5 lead to start the game, but the Titans responded with a 9–0 run to bring Detroit within a single score.

Eli Holman scored from under the rim to tie the game at 18–all, and Doug Anderson followed it up with a two-handed slam dunk to take the lead by two.

He went on to miss the front-end of a one–and–one, and Flames guard Daniel Barnes pulled down the rebound and hit two free throws to end the game in a 63–59 defeat for the Titans.

Detroit had an early 8–0 run in the second half to go up 34–26, and continued to hold Loyola at bay, stretching their lead into double digits multiple times.

The Ramblers got as close as 44–39 at the 8:44 mark from a layup by Denzel Brito, but the Titans never let up, defeating Loyola 65–54 and gaining their first conference win of the season.

Chase Simon led the team in scoring with 17, and Ray McCallum added 13 points, leading the Titans in rebounding (7) and assists (5).

The Crusaders' Jay Harris hit a layup to tie the game once again at 71–71, giving the Titans a chance to have the final shot with just 26 seconds remaining.

With still 10 seconds left, Chase Simon started driving inside the lane to the hoop, knocking a Valpo player over and being called for an offensive foul for charging.

With 5 seconds still left on the clock, Erik Buggs drove the length of the court and hit a layup at the buzzer to give Valparaiso the victory 73–71.