[2] FC Twente entered the season as reigning champions and finished as runners-up, behind ADO Den Haag.
[4] On 22 February 2011, leaders from the Eredivisie, the Royal Dutch Football Association (KNVB) and the clubs met to discuss possible improvement to the league.
The KNVB then announced that the league's matchdays would move from Thursdays to Fridays, relationship changes between clubs and their affiliated amateur clubs, guideline principles amongst other topics discussed, and the financial conditions were to be discussed on a further meeting, as the KNVB was trying to keep the league with eight teams.
[8] PSV Eindhoven, working to build a women's team, confirmed on 3 March 2011 it would not be able to participate in this season.
[14] Two weeks later, on 26 April 2011, as the club continued working to find sponsors to remain in the league, RBC Roosendaal presented a possibility of entering a team if its male team remained in Jupiler League.