The 2011–12 Amlin Challenge Cup pool stage was the opening stage of the 16th season of the European Challenge Cup, the second-tier competition for European rugby union clubs.

It began on 10 November 2011 with two matches and ended on 22 January 2012.

The pool winners advanced to the knockout stage, where they were joined by three entrants from the Heineken Cup pool stage.

These teams then competed in a single-elimination tournament that ended with the final at the Twickenham Stoop in London on 18 May 2012.

All times are local to the game location.