Plzeň started the season by defeating FC Pyunik in the second qualifying round of the UEFA Champions League, winning with an aggregate score of 9–1.

In the new year, Plzeň entered the UEFA Europa League round of 32, where they lost over two legs to German outfit Schalke 04, this was soon followed by an aggregate defeat to Mladá Boleslav in the Czech Cup.

As winners of the previous season's Gambrinus liga, Plzeň played defending cup champions Mladá Boleslav in the Czech Supercup on 22 July.

[2] Plzeň were seeded in the fourth pot for the draw, being drawn in Group H alongside defending champions Barcelona as well as A.C. Milan and BATE Borisov.

In the group stage, Plzeň played their home matches at Eden Arena in Prague due to the ongoing development of their own Stadion města Plzně.

[11] The last two games showed a marked improvement for Plzeň as they defeated BATE in Minsk and then scored two late goals to draw 2–2 with Milan in Prague.

However, the German side, in front of a crowd of over 50,000, scored two goals in the additional period, signalling the end of European football this season for Plzeň.