The 2011–12 season of Majstrovstvá regiónu was the nineteen season of the fourth-tier football league in Slovakia, since its establishment in 1993.
64 teams were geographically divided into four groups: Majstrovstvá regiónu Bratislava, Majstrovstvá regiónu Západ, Majstrovstvá regiónu Stred and Majstrovstvá regiónu Východ (16 teams each).
Teams were played against teams in their own division only.