They were replaced by the 2010–11 Slovenian Second League fourth-placed team, Mura 05, who participated in the competition for the first time in their history.
Mura 05 received and accepted an invitation to join the league after Aluminij, Interblock and Dravinja – who finished in the top three places – all declined promotion due to financial reasons.
[4] With both Nafta and Mura 05 participating in the 2011–12 edition, Prekmurje region had two teams in the top division for the first time since the 1999–2000 season.
The ninth-placed team of the 2011–12 PrvaLiga, Triglav Kranj, played a two-legged relegation play-off against the runners-up of the 2011–12 Slovenian Second League, Dob.
Although Triglav lost the two-legged play-off 6–0 on aggregate, they retained their place in PrvaLiga as Dob declined promotion due to financial reasons.