The champions of this season, St. Gallen, earned promotion to the 2012–13 Super League.
The runners-up Aarau lost the promotion/relegation playoff against the 9th-placed team of the 2011–12 Super League, FC Sion.
The bottom five teams, Stade Nyonnais, Étoile Carouge, Delémont, Kriens and Brühl were all relegated to partly form the newly created 1.
They were replaced by St. Gallen, who were relegated after finishing the 2010–11 Super League in last place.
They were replaced by SC Brühl and Étoile Carouge FC, who were promoted from 1.