The winner of each group was promoted to the 2012–13 TFF First League.
A play off series was played among the best four remaining teams in each group to determine the third team to promote.
The bottom three teams in each group were relegated to the 2012–13 TFF Third League.
Altay and Diyarbakırspor were relegated from 2010–11 TFF First League.
Altınordu, Denizli Bel., Gaziosmanpaşaspor, Kırklarelispor, Tepecikspor, Ünyespor were promoted from 2010–11 TFF Third League