Bangor City were the defending champions, but lost their title to The New Saints in a meeting on the final game of the season.
Haverfordwest County were relegated to the 2011–12 Football League Division One at the end of the 2010–11 season after finishing at the bottom of the table.
Originally, Bala Town as 11th-placed team were going to be relegated as well; however, they were eventually spared as 2010–11 Cymru Alliance champions Connah's Quay Nomads were denied a Premier League licence.
[1] Teams played each other twice on a home and away basis, before the league was split into two groups at the end of round 22 – the top six and the bottom six.
As Neath failed to win their appeal against an FAW Domestic licence, Aberystwyth Town took their place (See Relegation Section)