Caroní and Atlético Venezuela were relegated after accumulating the fewest points in the 2010–11 season aggregate table.
They will be replaced by Llaneros and Tucanes, the 2010–11 Segunda División winner and runner-up, respectively.
Source:[1] Because Deportivo Lara won both the Apertura and Clausura, the Serie Final was not played, and Deportivo Lara was declared champion automatically.
Other than the teams which already qualify for the Copa Libertadores (Apertura and Clausura champions and the best-placed team in the aggregate table) and the Copa Sudamericana (Copa Venezuela champion), the eight best-placed teams in the aggregate table will contest in the Serie Sudamericana for the remaining two berths to the Copa Sudamericana, which qualify the two winners to the First Stage.
In the first round, the matchups are: In the second round, the matchups are: For the two second round winners, the team with the better record in the aggregate table will receive the Venezuela 3 berth, while the other team will receive the Venezuela 4 berth.