All six group matches were played at venues in the United States, in Detroit, Tampa and Kansas City.
The match marked the first time in Gold Cup history that the United States lost on its home soil during Group Stage play.
It was also the first time since the 1985 CONCACAF Championship, that the United States lost on home ground in a continental tournament.
Panama's Gabriel Enrique Gómez converted a penalty kick in the 33rd minute, which ended up being the winner.
All Times are U.S. Eastern Daylight Time (UTC−4) (Local Times in parentheses) Assistant referees: José Luis Camargo Callado (Mexico) Ainsley Rochard (Trinidad and Tobago) Fourth official: Marco Rodríguez (Mexico) Assistant referees: Daniel Williamson (Guatemala) Oscar Velasquez (Guatemala) Fourth official: Trevor Taylor (Barbados) Assistant referees: Adrian Goddard (Barbados) Gerson Lopez (Guatemala) Fourth official: Marlon Mejía (El Salvador) Assistant referees: José Luis Camargo Callado (Mexico) Alberto Morín Méndez (Mexico) Fourth official: Jeffrey Solís (Costa Rica) Assistant referees: Gerson López (Guatemala) Hermenerito Leal (Guatemala) Fourth official: Marco Rodríguez (Mexico) Assistant referees: José Luis Camargo Callado (Mexico) Alberto Morín Méndez (Mexico) Fourth official: Marlon Mejía (El Salvador)