The regular season started on Saturday, February 26, with the expansion Port Huron Predators defeating the expansion Indianapolis Enforcers 69-12, and ended with the 2011 CIFL Championship Game on June 11, 2011, at the Cincinnati Gardens in Cincinnati, Ohio, where the Cincinnati Commandos defeated the Marion Blue Racers 44-29 to clinch their second consecutive CIFL Championship.
There were changes to the teams that made up the 6 teams, as Fort Wayne FireHawks, Marion Mayhem and the Wisconsin Wolfpack folded following the 2010 season, and the Chicago Cardinals changed their name to the Chicago Knights, and the Miami Valley Silverbacks established a home arena in Dayton, Ohio and changed their names to the Dayton Silverbacks.
The CIFL awarded the Indianapolis Enforcers, the Marion Blue Racers and the Port Huron Predators expansion franchises.
On April 29, 2011 it was announced that the Port Huron Predators would ceased operations immediately.
The league launched the Gameday Center on its website that would allow followers to enjoy live stats for each game.
Shepard, who was the Dayton Silverbacks' head coach in 2009 before he was replaced prior to the 2010 regular season, after posting a 0-10 record.
[3] On March 28, the Predators fired their second coach of the season as well as their director of operations.
Head Coach Jason Lovelock was let go after Brusate said, "The players wanted something different."
Brusate appointed offensive coordinator, John Forti, as the interim head coach.