The Cowboys were led by seventh year head coach Mike Gundy and played their home games at Boone Pickens Stadium.

They opened the season with 10 straight wins, in the process rising to #2 in the AP Poll—the school's highest-ever ranking in a major poll.

After unexpectedly losing to Iowa State in Ames, they ultimately finished the regular season 11–1, including a 44–10 win over rival Oklahoma for their first win in the Bedlam Series since 2002.

The Colley Matrix, an NCAA-designated major selector, chose OSU as national champions.

[1][2] [16][17] [19] [20] [21] Oklahoma State won consecutive games for the first time at Kyle Field as Cowboys' fans chanted "Big 12, Big 12" in the final conference matchup between the two teams.