Led by second-year by head coach Tommy Tuberville, the Red Raiders compiled an overall record of 5–7 with a mark of 2–7 in conference play, placing ninth in the Big 12.

The Red Raiders opened their 2011 season at home against the Texas State Bobcats, marking the 950th overall contest in the program's 86-year history.

On the next play, Bobcats' quarterback Shaun Rutherford was penalized for intentional grounding which resulted in safety giving the Red Raiders' two more points and the ball back.

The final touchdown of the game came on the next Red Raider drive with 3 yard pass to Eric Ward from backup quarterback Jacob Karam.

[5] Despite two weather delays in the game caused by lightning strikes nearby, the Red Raiders rolled to a 59–13 rout of the Lobos.

[7] Doege connected on a pair of first-quarter touchdown passes to Darrin Moore as the Red Raiders jumped out to a 14–0 lead.

Texas Tech's domination continued in the third quarter as Doege threw scoring passes to Ward and tight end Jace Amaro.

Texas Tech's final touchdown in the fourth quarter came as true freshman Ronnie Daniels, a graduate of Albuquerque's La Cueva High School, ran in the ball from nine yards out.

Doege was named the Big 12 Conference Co-offensive Player of the Week for his record performance, sharing the honor with Missouri running back Henry Josey.

Seth Doege rallied the Red Raiders from a two-score third quarter deficit to win 35–34 with the game-winning touchdown toss to Eric Ward with 36 seconds left.

Wolf Pack quarterback Cody Fajardo broke loose for a 56-yard touchdown to give Nevada a 28–14 lead over the Red Raiders with 5:29 remaining in the third quarter, but Texas Tech's defense held Nevada to a pair of field goals in the fourth quarter as the Red Raiders mounted their comeback.

Trailing 34–28, the Red Raiders got the ball with less than 5 minutes remaining and drove 56 yards in 9 plays for the winning score.

Johnson intercepted Webb again on Kansas's next possession, and Doege found Jacoby Franks for a 13-yard touchdown to give Texas Tech a 21–20 lead halfway through the second quarter.

Texas Tech's final touchdown pass came after an interception by Red Raider linebacker Cquilin Hubert in the end zone.

Texas Tech's offense added a pair of Donnie Carona field goals and a touchdown run by Eric Stephens to stay within 11 points at halftime.

Texas Tech's offense had 580 yards to Kansas State's 339, but several key mistakes would lead to the Red Raiders' defeat.

On the ensuing kickoff, Tyler Lockett returned Carona's kick 100-yards for a touchdown, but Anthony Cantele missed the extra point.

The Red Raiders' victory over the Sooners ended Oklahoma's 39-game home winning streak, which started in 2005 after a loss to TCU in the season opener.

The game was the Sooners’ first Big 12 Conference loss at Owen Field since 2001, and only the third time the team has lost at home under Bob Stoops.

[15][16] The Red Raiders were named the Tostitos Fiesta Bowl National Team of the Week for games of the weekend of October 22.

[17] Seth Doege threw for 441 yards and four touchdown passes, three of them to Alex Torres, as the Red Raiders built a 24–7 halftime lead.

A week after upsetting Oklahoma, Texas Tech hosted Iowa State, which came into the game with a 3–4 record and a 0–4 mark in Big 12 play.

However, the Cyclones scored on their opening possession of the second half, and their defense shut out the Raiders for the rest of the game as they held on for a 41–7 rout.

The Red Raiders only scored once during the entire game, with Cornelius Douglas recovering a fumble and returning it 37 yards for a touchdown.

On the next drive, the Red Raiders marched down the field to the Tigers' 7-yard line, but a Seth Doege pass was intercepted by Michael Sam (Texas Tech's only turnover of the game) with 0:32 left to play.

Texas Tech attempted and recovered an onside kick on the ensuing kickoff, but the drive ended with a punt.

Seth Doege threw two interceptions while running back Kenny Williams and wide receiver Adam Jones both each lost a fumble.