A total of 18 teams are competing in the league due to a two team expansion, with Muangthong United as the defending champions.

The season started on 12 February 2011 and is generally broken down into 2 legs.

Bangkok United were relegated to the 2011 Thai Division 1 League after finishing the 2010 season in the bottom three places and lost in promotion/relegation play-off.

2010 Thai Division 1 League champions Sriracha, runners-up Khonkaen and third place Chiangrai United were promoted to the Thai Premier League.

Updated to games played on January 28, 2011Source: Thai Premier LeagueNotes:† Team played previous season in Division 1 League.