Novak Djokovic defeated defending champion Rafael Nadal in a rematch of the previous year's final, 6–2, 6–4, 6–7(3–7), 6–1 to win the men's singles tennis title at the 2011 US Open.

[1][2] Djokovic saved two match points en route to the title, against Roger Federer in the semifinals.

[3] This was the second consecutive US Open where Djokovic saved two match points against Federer to reach the final, and the fifth consecutive US Open where Djokovic and Federer played each other.

[4] Federer's defeat meant that he did not win a major in a calendar year for the first time since 2002.

Andy Roddick and John Isner, who both lost in the quarterfinals, became the last American men to reach the quarterfinals of a major until Sam Querrey at the 2016 Wimbledon Championships, a span of 22 events.