The 2011 Winston-Salem Open was a men's tennis tournament played on outdoor hard courts.

It was previously known as the Pilot Pen Tennis but was relocated to Winston-Salem.

It was the 43rd edition of the Winston-Salem Open, and was part of the ATP World Tour 250 series of the 2011 ATP World Tour.

Fourth-seeded John Isner won the singles title.

The following players received wildcards into the singles main draw The following players received entry from the qualifying draw: The following players received entry from a lucky loser spot: John Isner defeated Julien Benneteau, 4–6, 6–3, 6–4 Jonathan Erlich / Andy Ram defeated Christopher Kas / Alexander Peya, 7–6(7–2), 6–4