[16] Notable player departures during the offseason included pitcher Cliff Lee and outfielder/designated hitter Vladimir Guerrero (both to free agency) and catcher Bengie Molina, who retired.

Notable free agent additions during the offseason included pitchers Yoshinori Tateyama and Brandon Webb, catcher Yorvit Torrealba, and third-baseman Adrián Beltré.

During the 2010 offseason, the team signed new contracts with manager Tony La Russa and picked up All-Star slugger Albert Pujols' club option.

Additionally, during the offseason the team announced that ace pitcher Adam Wainwright would miss the entire season due to Tommy John surgery.

Notable offseason additions included shortstop Ryan Theriot, outfielder Lance Berkman, catcher Gerald Laird, and infielder Nick Punto.

In the fourth after a controversial call at first base by umpire Ron Kulpa on a force play and subsequent single put runners on first and second with one out, David Freese's RBI double made it 2–0 Cardinals.

After an intentional walk loaded the bases, two runs scored on a throwing error by Mike Napoli before Ryan Theriot's RBI single made it 5–0 Cardinals.

Lance Lynn relieved Salas and allowed an RBI single to Adrian Beltre, then, one out later, a sacrifice fly to Napoli to make it 8–6 Cardinals.

Albert Pujols, who had been hitless through the first two games, then hit a 423 ft (129 m) home run off Alexi Ogando in the sixth inning after a leadoff single and walk to make it 11–6 Cardinals.

The Cardinals added to their lead in the eighth when Freese singled with one out off of Mark Lowe and pinch-runner Daniel Descalso scored on Molina's double.

Albert Pujols joined Babe Ruth (1926, 1928) and Reggie Jackson (1977) as the only players in baseball history up to that time to hit three home runs in a World Series game.

The Rangers' half of the eighth featured a series of bullpen mix-ups by the Cardinals, leaving Tony La Russa without closer Jason Motte in a crucial situation.

After Michael Young led off the inning with a double, La Russa sent both Motte (a right-hander) and left-handed reliever Marc Rzepczynski to begin warmups.

Although rain was only falling fairly lightly in St. Louis when this decision was made, MLB officials did not want a repeat of Game 5 of the 2008 World Series (which was suspended after the top of the sixth inning and resumed two days later).

David Freese started off the top of the fifth by dropping a routine pop fly (the third consecutive half-inning to begin with an error), which immediately turned into the go-ahead run for Texas on Young's double.

With the Cardinals in a prime position to rally ahead, Matt Holliday, standing 90 feet (27 m) away as the possible go-ahead run, was picked off at third by catcher Mike Napoli.

Lance Lynn came on to pitch for the Cardinals in the top of the seventh and was promptly greeted with back-to-back home runs by Adrián Beltré and Nelson Cruz to put Texas up by two.

Down to his last strike, Freese hit Feliz's pitch past a leaping Nelson Cruz off the right field wall for a triple, tying the game at seven.

St. Louis players Daniel Descalso and Jon Jay hit back-to-back singles, and starting pitcher Kyle Lohse was called to bunt.

Ryan Theriot's RBI groundout scored Descalso, cutting the Rangers' lead to 9–8, and following an intentional walk to Pujols, Berkman stepped up to the plate.

[51][52] Freese joined Jim Edmonds, the man for whom he was traded, as the only players in Cardinals history to hit an extra-inning walk-off home run in the postseason.

He also joined Aaron Boone (2003), David Ortiz (2004) and Hall of Famers Carlton Fisk (1975) and Kirby Puckett (1991) as the only players to hit an extra-inning walk-off home run when their team was facing postseason elimination.

[61]Josh Hamilton and Michael Young had RBI doubles in the first inning against Chris Carpenter, who became the first pitcher in a decade[62] to make three starts in one Series thanks to the unnecessary postponement of Game 6 due to forecasted rain that did not occur.

David Freese had a game-tying two-run double in the bottom of the first, breaking the postseason RBI record, and Allen Craig hit a go-ahead homer in the third.

Yadier Molina walked with the bases loaded, C. J. Wilson came on to relieve Feldman and promptly hit Rafael Furcal with his first pitch, forcing in another run to make it 5–2.

[68] In Game 7 of the World Series, Freese hit a two-run double in the bottom of the first inning, bringing his 2011 postseason RBI total to 21, an MLB record.

Ken Rosenthal served as field reporter for the games, while Chris Rose hosted the pregame and postgame coverage with analysts A. J. Pierzynski and Eric Karros.

"[91] On December 7, the Houston Astros hired Jeff Luhnow as their general manager, culminating his rise through the Cardinals ranks as a top player developer.

Along with Luhnow, John Mozeliak helped fulfill owner Bill DeWitt, Jr.'s mission to make Cardinals' farm system a consistent producer of prospects who would be key in the club's success.

The Rangers would return to the World Series again in 2023, where they would finally win it all as they defeated the Arizona Diamondbacks 4 games to 1 to clinch their first title in franchise history.