The División de Honor Femenina 2012–13 was the 56th season of women's handball top flight in Spain since its establishment.
The season began on Saturday, 8 September 2012.
A total of 14 teams contested the league, 10 of which had already contested in the 2011–12 season, and four of which were promoted from the División de Plata 2011–12.
Bera Bera clinched its first title by winning in the last matchday to Castro Urdiales 18–32.
Teams promoted from 2011–12 División de Plata Teams relegated to 2011–12 División de Plata Teams dissolved