Everton entered the FA Cup in the third round and progressed to the quarter-finals where they suffered a 3–0 loss at home to Premier League relegation candidates Wigan Athletic.

[4] On 1 June 2012, Everton's first pre-season friendly fixtures were announced: an away game against League Two side Morecambe acting as a testimonial to Morecambe's player-manager Jim Bentley, and a second away fixture against Scottish Premier League side Dundee United,[5] and on 7 June 2012 a second match to be played in Scotland was announced, against Motherwell F.C.

[6] A further three friendly fixtures were later determined: a home game against AEK Athens as a testimonial match for Everton's long-serving defender Tony Hibbert,[7] and away matches against Blackpool and Spanish side Málaga, the latter serving as the 29th edition of the annual Trofeo Costa del Sol friendly competition.

[12] On 26 July, Tim Cahill's eight-year stay at the club came to an end when he signed for the New York Red Bulls in a £1 million deal.

[13] On 31 July, Steven Pienaar, who had made a significant impact during his loan spell at the end of last season, signed permanently for the club for £4.5 million and thus began his third stint at Everton.

[14] On 6 August, Fenerbahçe completed a £2 million move for Joseph Yobo, who had not played for Everton since May 2010 due to two season-long loans at the Turkish side.

[17] On 19 August, Belgium international Kevin Mirallas signed for the club from Greek champions Olympiacos for a £6 million fee.

[20] On 29 August, new signing Mirallas scored his first and second goals for the club during an emphatic 5–0 League Cup win over Leyton Orient to help Everton advance to the third round.

[21] On 31 August, the final day of the summer transfer window, Everton signed versatile Costa Rican international Bryan Oviedo from Danish side Copenhagen for an undisclosed fee, believed to be £5 million.

[22] On 1 September, Everton missed the chance to extend their unbeaten run in the league to 12 games when they lost 0–2 to West Bromwich Albion.

[25][26] On 25 September, Everton were knocked out of the League Cup following a 1–2 defeat by Championship side Leeds United in the third round at Elland Road.

[36] On 15 December, Fellaini again made the headlines for allegedly headbutting Ryan Shawcross in Everton's 1–1 draw at Stoke City.

Wigan's consolation goal also meant that Everton had failed to keep a clean sheet in any of the previous 14 games they had played.

On 30 December, Everton lost to Chelsea at home, ending an unbeaten run at Goodison Park that stretched back to March.

[38] On 7 January, Everton progressed to the fourth round of the FA Cup with a 5–1 away win at League Two side Cheltenham Town.

On 2 February, Everton rallied from a two-goal deficit to draw at home with relegation strugglers Aston Villa.

On 16 February, Everton conceded an injury time equaliser to Oldham Athletic in the fifth round of the FA Cup, forcing a replay at Goodison Park at the end of the month.

[43] On 9 March, Everton crashed out of the FA Cup with a 0–3 home defeat by Premier League relegation candidates Wigan, with all three goals coming in less than four first-half minutes.

[44] On 16 March, Everton bounced back in the league to beat reigning champions Manchester City 2–0 at Goodison Park, despite playing with ten men from the 60th minute with the score at 1–0, when Steven Pienaar was dismissed.

On 5 April, Moyes was named Premier League Manager of the Month for March, the second time he has won the award this season and the tenth in total.

Source: Everton Matches Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.