Real Mamoré finished last in the 2011 relegation table and was relegated to the Liga Nacional B for the first time since the club was founded.
They were replaced by the 2011–12 Liga Nacional B champion Petrolero.
A playoff was contested between the third-placed teams of the 2011/12 Clausura (Oriente Petrolero) and the 2012/13 Apertura (Bolívar).
The winner qualified for the 2013 Copa Libertadores First Stage, while the loser qualified for the 2013 Copa Sudamericana First Stage.
Updated as of games played on May 6, 2013.Source:[1] Source:[2]