F91 Dudelange were the defending champions having won their tenth league championship in the previous season.
US Rumelange and US Hostert were relegated to the Division of Honour after finishing 13th and 14th in the previous season.
They were replaced by 2011–12 Division of Honour champions Jeunesse Canach and runners-up Etzella Ettelbruck.
Hesperange as 12th-placed team had to compete in a single play-off match against third-placed Division of Honour side Wiltz.
Wiltz won the match by 6–2, and they returned to the top division after a one-year absence.