The Syracuse Orange women represented Syracuse University in CHA women's ice hockey during the 2012-13 NCAA Division I women's ice hockey season.

The goaltending duo of Kallie Billadeau and Jenesica Drinkwater registered 8 shutouts between them.

[6] Flanagan earned his 300th career win on February 27.

Junior Defense Akane Hosoyamada was named to the All-CHA First Team, along with Junior Goaltender Kallie Billadeau.

Defender Nicole Renault was named to the All-Rookie Team.