The 2012–13 season was Sampdoria's 66th in existence.

Sampdoria finished the 2011–12 season in sixth place in Serie B and were promoted to Serie A through the play-offs.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

The list is sorted by shirt number when total goals are equal.