2012 AFC Champions League knockout stage

In the quarter-finals and semi-finals, each tie was played over two legs on a home-and-away basis.

[1] The matchups for the round of 16 were decided based on the results from the group stage.

[2] After the completion of the round of 16, the draw for the quarter-finals, semi-finals, and final was held at the AFC house in Kuala Lumpur, Malaysia on 14 June 2012, 16:00 UTC+08:00.

While the bracket below shows the entire knockout stage, the draw for the round of 16 matches was determined at the time of the group draw, and kept teams from West Zone and East Zone completely separate for that round.

The final of the 2012 AFC Champions League was hosted by one of the finalists, decided by a draw.