The Arizona Diamondbacks' 2012 season, was the franchise's 15th season in Major League Baseball and also their fifteenth season at Chase Field.

The Diamondbacks finished with a record of 81–81, third place in the National League West.

Right-handed pitchers Trevor Cahill and Takashi Saito were all acquired by the D-Backs in the offseason, along with slugging left-handed left fielder Jason Kubel and left-handed reliever Craig Breslow.

Infielders Coaches Note: G = Games played; AB = At bats; R = Runs scored; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; SB = Stolen bases; AVG = Batting average Note: W = Wins; L = Losses; ERA = Earned run average; G = Games pitched; GS = Games started; SV = Saves; IP = Innings pitched; H = Hits allowed; R = Runs allowed; ER = Earned runs allowed; BB = Walks allowed; K = Strikeouts League Champions: Reno, Mobile, Missoula