They completed the regular season with a 93–69 record, good for second place in the AL East and qualified for one of two American League wild card spots.

[1] On May 6, the Orioles won a marathon 17-inning game over the Boston Red Sox with the pitching win credited to designated hitter Chris Davis.

The Orioles clinched their first non-losing season since 1997 on September 13, 2012, winning their 81st game on a walk-off single by Manny Machado in the bottom of the 14th inning against the Tampa Bay Rays.

After falling in extra innings to the New York Yankees on back-to-back nights in early April, the Orioles went 16–0 in extra-inning games through the rest of the season.

The following players represented the Orioles in the 2012 Major League Baseball All-Star Game The following players received Gold Glove Awards for the 2012 MLB season The Orioles took on the Texas Rangers in Arlington, Texas in the inaugural Wild Card "winner-take-all" format game for the right to play the New York Yankees in the 2012 American League Division Series, who are the top seed finishing with the best record in the AL at 95–67.