The 2012 Charleston Southern Buccaneers football team represented Charleston Southern University as a member of the Big South Conference during the 2012 NCAA Division I FCS football season.
Led by Jay Mills in his tenth and final season as head coach, the Buccaneers compiled an overall record of 5–6 with a mark of 3–3 in conference play, placing fourth in the Big South.
Charleston Southern played home games at Buccaneer Field in Charleston, South Carolina.
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