2012 Copa Libertadores knockout stage

If still tied after extra time, the title would be decided by penalty shootout.

In each tie, the higher-seeded team played the second leg at home.

Tied on points 3–3, Universidad de Chile won on goal difference.

Tied on points 3–3, Vasco da Gama won on penalties.

Tied on points 2–2, Universidad de Chile won on penalties.

If the teams were tied on points and goal difference at the end of regulation in the second leg, the away goals rule would not be applied and 30 minutes of extra time would be played.

If still tied after extra time, the title would be decided by penalty shootout.