At the drop of the green flag, Kasey Kahne led, and continued to lead for the first ten laps.
On lap 17, the first caution came out for a three car crash in turn 4 that eliminated Carl Edwards and Cole Whitt from contention, and also gave some heavy damage to Joey Logano.
One lap later, Kenseth got loose off of Greg Biffle's bumper, and he went from 1st to 31st place in a matter of seconds, while Earnhardt Jr. received the lead.
These penalties ultimately resulted in Earnhardt Jr. and Busch being trapped a lap down for a significant chunk of the mid-portion of the race.
Two laps after that, the second caution of the race waved when Kasey Kahne ran out of fuel, and simultaneously, Busch was spun out on the back straightaway by Jamie McMurray.
Although the car took damage from hitting the inside wall, Busch was able to refire the engine, after the emergency crews had already reached him.
A medical bag that was sitting on top of the car was subsequently thrown from the back decklid.
NASCAR parked Busch for pulling away and trying to drive back to the garage despite the fact that his car was shedding debris.
On lap 182, Kenseth claimed the lead, and the fourth caution came out as McMurray spun out in the tri-oval off of Harvick's bumper.
Under the caution, 11 drivers did not pit, so Clint Bowyer led the field at the restart on lap 187.
During the Green-White-Checkered attempt, Ryan Newman tried to squeeze it four-wide in between Casey Mears and Jimmie Johnson in the middle of the pack in turn 2 and was able to not cause a wreck.
Before the White Flag was waived, the pack behind Stewart and Kenseth had all bunched up to four-wide going four-rows back.
In turn four, Casey Mears started pushing Michael Waltrip and the pair made a move on the inside of Stewart.
Overall, the wreck collected Dale Earnhardt Jr., Kevin Harvick, Denny Hamlin, Bobby Labonte, Terry Labonte, Jimmie Johnson, Kasey Kahne, Aric Almirola, Dave Blaney, Regan Smith, Michael Waltrip, Casey Mears, Brad Keselowski, Clint Bowyer, David Ragan, Paul Menard, Marcos Ambrose, Martin Truex Jr., David Gilliland, Kyle Busch, Sam Hornish Jr., Jeff Burton, Greg Biffle, Travis Kvapil, and Tony Stewart.
Kenseth was the only one in front of the crash and he made it to the finish line to win the race followed by Jeff Gordon and Kyle Busch, who got through by going down to the apron.
Greg Biffle and Ryan Newman, who were on the outside back of the four-wide pack before the crash, managed to avoid it by slowing down and weaving through out-of-control cars to finish in sixth and ninth place respectively.