The Mets finished with a 74–88 record, fourth place in the National League East, and missed the postseason for the sixth straight year.

The Mets wore two patches, one commemorating the team's 50th anniversary and another honoring Gary Carter, who died of brain cancer on February 16, 2012.

[7] On June 1, Johan Santana made club history by becoming the first Mets pitcher to throw a no-hitter, in an 8–0 victory over the St. Louis Cardinals.

This was also the first no-hitter to be pitched against a defending World Series champion since a former Met, Nolan Ryan, did it against the Oakland Athletics in their 1990 pennant season while with the Texas Rangers.

[8][9] On June 27 against the Chicago Cubs, the Mets became the first major league team to hit a home run cycle.

In the sixth inning, Scott Hairston, who was typically a utility outfielder throughout the first half of the season, hit the cycle ending grand slam off of Coleman.