The 2012 Open de Nice Côte d'Azur was a men's tennis tournament played on outdoor clay courts.

It was the 28th edition of the Open de Nice Côte d'Azur and was part of the ATP World Tour 250 series of the 2012 ATP World Tour.

It took place at the Nice Lawn Tennis Club in Nice, France, from 21 May through 27 May 2012.

Third-seeded Nicolás Almagro won the singles title.

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following pairs received wildcards into the doubles main draw: