Fifty-four of the 100 seats in the Senate were up for election with the winning candidates serving six-year terms.

After the election, on 12 March 2012, Nayyar Hussain Bukhari of the ruling Pakistan People's Party (PPP) was elected to the position of Chairman unopposed.

On the same day, Sabir Ali Baloch, also of the PPP, elected to the position of Deputy Chairman unopposed.

They replaced Farooq Naek of the PPP and Jan Mohammad Jamali of the Pakistan Muslim League (Q) (PML(Q)), respectively.

Moreover, on 27 April 2012, Jehangir Bader of the PPP succeeded Bukhari as the Leader of the House, and on 15 March 2012, Ishaq Dar of the Pakistan Muslim League (N) (PML-N) became the Leader of the Opposition, succeeding Abdul Ghafoor Haideri of the Jamiat Ulema-e-Islam (F) (JUI-F).