The 2012 S.League was the 17th season of the S-League, the top professional football league in Singapore.

Tampines Rovers won their fourth title, finishing top of a 13-team league.

Etoile FC withdrew their participation in the league to concentrate on grassroots football and youth development.

DPMM FC have re-entered the league, coming back since they were suspended by FIFA in the 2009 campaign.

Harimau Muda of Malaysia have also entered the fray.