The 2012 Serbia Open (also known as Serbia Open 2012 powered by Telekom Srbija for sponsorship reasons) was a men's tennis tournament play on outdoor clay courts.

The fourth edition of the event was hosted by Serbian player Novak Djokovic.

It took place at the Tennis Center Novak complex in Belgrade, Serbia, from 28 April through 6 May 2012.

Andreas Seppi won the singles title.

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following pairs received wildcards into the doubles main draw: Andreas Seppi defeated Benoît Paire, 6–3, 6–2 Jonathan Erlich / Andy Ram defeated Martin Emmrich / Andreas Siljeström, 4–6, 6–2, [10–6]