The 2012 South Alabama Jaguars football team represented the University of South Alabama in the 2012 NCAA Division I FBS football season.

They were led by fourth-year head coach Joey Jones and played their home games at Ladd–Peebles Stadium.

As part of their two-year transition to the FBS from the FCS, the Jaguars were not eligible for the Sun Belt championship and were not eligible to play in a bowl game.

On April 11, inside linebacker coach Kurt Crain was found dead in Spanish Fort, Alabama from an apparent self-inflicted gunshot wound.

This college football 2010s season article is a stub.