The 2012 Southern Illinois Salukis football team represented Southern Illinois University Carbondale as a member of the Missouri Valley Football Conference (MVFC) during the 2012 NCAA Division I FCS football season.

Led by fifth-year head coach Dale Lennon, the Salukis compiled an overall record of 6–5 with a mark of 5–3 in conference play, placing in a three-way tie for third in the MVFC.

Southern Illinois played home games at Saluki Stadium in Carbondale, Illinois.