The 2012 Southern Miss Golden Eagles football team represented the University of Southern Mississippi in the 2012 NCAA Division I FBS football season as a member of the East Division of Conference USA.

They were led by first-year head coach Ellis Johnson and played their home games at M. M. Roberts Stadium in Hattiesburg, Mississippi.

The 2012 squad finished the season winless with a final record of 0–12[1] one year after finishing 12–2 and winning the conference championship.

The biggest single season decline in FBS history, [2]and after only one year at the helm, Johnson along with his entire staff were fired.

This college football 2010s season article is a stub.