The 2012 Texas Southern Tigers football team represented Texas Southern University a member of the West Division of the Southwestern Athletic Conference (SWAC) during the 2012 NCAA Division I FCS football season.

Led by first-year head coach Darrell Asberry, the Tigers compiled an overall record of 2–9 with a mark of 2–7 in conference play, placing fourth in the SWAC's West Division.

[2] Texas Southern was barred from postseason football play for the 2012 season due to falling short in fulfilling the NCAA graduation rate requirements.

[4] Sources: [5][6] Texas Southern holds an 18-8 advantage in the Labor Day Classic, but Prairie View A&M had won the most recent 5 games headed into this game.

[7] [8] Roster Texas Southern football games were carried live on KTSU 90.9 FM.