2012 Regional League Division 2 Central & Eastern Region is the 4th season of the League competition since its establishment in 2009.
It is in the third tier of the Thai football league system.
Ratchaburi were promoted to the 2012 Thai Division 1 League after winning the 2011 Regional League Division 2 championship pool.
Maptaphut Rayong, Royal Thai Fleet, Thanyaburi RA United re-located to the Regional League Central-East Division from the Regional League Bangkok Area Region 2011.
Trat joined the newly expanded league setup.