The 2012 Tour de San Luis was the 6th edition of the Tour de San Luis stage race.

It was part of the 2011–12 UCI America Tour.

[1] Levi Leipheimer of Omega Pharma–Quick-Step won the race, mainly in the time-trial, which he won and where he made the difference with second placed Alberto Contador, who did win two mountain stages.

With 2 stage wins for Francesco Chicchi and one for Tom Boonen, Omega Pharma–Quick-Step scored an impressive 4 wins out of 7.

Italian Elia Viviani also managed to win one stage.