Andy Murray defeated defending champion Novak Djokovic in the final, 7–6(12–10), 7–5, 2–6, 3–6, 6–2 to win the men's singles tennis title at the 2012 US Open.

Murray was the first British man to win a singles major since Fred Perry in 1936.

This tournament marked the last professional appearance of 2003 champion and former world No.

1 Andy Roddick; he lost to Juan Martín del Potro in the fourth round.

This tournament marked the first time since the 2004 French Open that neither Roger Federer nor Rafael Nadal (who withdrew from the tournament due to a knee injury) reached the semifinals of a major.