Maine voters chose four electors to represent them in the Electoral College via a popular vote pitting incumbent Democratic President Barack Obama and his running mate, Vice President Joe Biden, against Republican challenger and former Massachusetts Governor Mitt Romney and his running mate, Congressman Paul Ryan.

[1] As of the 2024 presidential election, this is the last election that the Democratic candidate won Maine's second congressional district along with a majority of counties in the state, as well as these counties (all of which comprise that district): Androscoggin, Aroostook, Franklin, Oxford, Penobscot, Somerset, and Washington.

The Republican caucuses were held between Sunday, January 29, and Saturday, March 3, at various locations throughout the state of Maine.

[4] On Saturday, February 11, after 84% of precincts had completed voting, state-party officials announced results of straw polls.

All three statewide totals showed former Governor Mitt Romney leading Representative Ron Paul by small margins, with other candidates well behind.