The winners qualified for the play-off round of the 2014–15 UEFA Europa League and the 2014 Belgian Super Cup.
Genk were the defending champions, but they did not retain their title as they were eliminated at the quarter-final by Oostende.
Lokeren won the trophy after beating Zulte Waregem 1-0 in the final on 22 March 2014.
The quarter- and semifinals will be played over two legs, where the team winning on aggregate advances.
On top of these fixtures, 8 teams received a bye to the second round, namely Torpedo Hasselt (6), Belgica Edegem (6), Wilrijk (6), Assesse (6), Spy (5), Couvin-Mariembourg (4), Gouy (6) and Wellin (5).
[6] The 16 teams from the Belgian Pro League entered at this stage, and each will play one of the 16 winners from the previous round.