[2] On November 7, senior forward David Pellom underwent knee surgery which was expected to prevent him from playing for five weeks.

The Tigers defeated the Cowboys by 5, marking Josh Pasner's first win over an AP top 25 team.

The inaugural AAC conference season began on New Year's Eve, where the Tigers faced South Florida on the road.

In the Tigers' second AAC game, they faced the 12–2 Cincinnati Bearcats at the Forum in a renewal of an old rivalry between the new conference mates.

However, Cincinnati pulled away in the second half while Memphis shot poorly from the outside, ending the game 2 for 17 from three-point range.

After the game, Coach Pastner and the team were heckled by Louisville fans who called the Tigers "thugs" and "classless."

[6] The Tigers suffered their only loss to a team with a losing record at the hands of the Houston Cougars on February 27.

The #19 Tigers entered the AAC tournament with a 12–6 record in conference and in a three-way tie for third with SMU and UConn.

The Tigers earned an at large bid to the 2014 NCAA tournament, where they were placed in the East region as an 8 seed.

The 11 games against ranked opponents and 5 top 25 wins both were the most recorded by the Tigers in a season since Josh Pastner became coach in 2009.