The reigning champions entering the season were Leicester Tigers, who had claimed their tenth title after defeating Northampton Saints in the 2013 final.
Northampton Saints won their first title after defeating Saracens in the final at Twickenham after having finished second in the regular season table.
As usual, round 1 included the London Double Header at Twickenham, the tenth instance since its inception in 2004.
[4] Gloucester 7s won the Series Final, beating Leicester Tigers 7s 24 – 17 and with it qualification to the inaugural World Club 7s at Twickenham.
All games in Round 22 kicked off at 15:15 on 10 May 2014, so as to not give any team a potential advantage with regards to knowing how to achieve a play-off berth, European Rugby Champions Cup place, or safety from relegation.