The Tigers competed in the Atlantic Coast Conference (ACC) and were led by twentieth-year head coach Jack Leggett.
Also in non-conference play, it included weekend series against William & Mary, Wright State, and Georgia Southern, along with midweek games against other mid-major programs.
Three players in the recruiting class– Tyler Krieger, Kevin Bradley, and Clate Schmidt– were selected in the 2012 Major League Baseball draft but chose to attend college.
Senior pitcher Scott Firth was named to the National Collegiate Baseball Writers Association (NCBWA) Stopper of the Year Award Watchlist.
[8][9] Leggett and other head coaches supported the new baseball in response to the drop in offense following the adoption of BBCOR bats in the 2011 season.
[10] In the preseason ACC coaches' poll, released in late January, Clemson was picked to finish third in the six-team Atlantic Division.
[15] Its opening day lineup was as follows: senior center fielder Thomas Brittle, sophomore left fielder Tyler Slaton, junior second baseman Steve Wilkerson, junior designated hitter Shane Kennedy, junior first baseman Jon McGibbon, sophomore third baseman Jay Baum, freshman right fielder Steve Duggar, freshman shortstop Tyler Krieger, and sophomore catcher Garrett Boulware.
In Friday's opening day game on February 15, Clemson won, 2–0, as a result of Kennedy's two-run home run in the bottom of the eighth.
With the 6–0 and 7–0 wins, Clemson recorded back-to-back shutouts for the first time since shutting out Presbyterian and USC Upstate on consecutive days in 2009.
Winthrop won the game, 3–2 in 11 innings, scoring the go-ahead run on a Clay Altman sacrifice fly in the top of the 11th.
"[31] In addition to Clate Schmidt's joining the weekend rotation, the lineup changed slightly, with freshman outfielder Maleeke Gibson appearing in more games in left field than sophomore Tyler Slaton.
[32] In game one at Clemson home field Doug Kingsmore Stadium on Friday, March 1, South Carolina won, 6–0.
Clemson had only three hits and committed three errors, including a dropped fly ball by Shane Kennedy in South Carolina's three-run seventh inning.
Similarly to Friday's loss, Clemson's offense had only three hits, and five of the six runs given up by starter Scott Firth were unearned.
[41] In the season's fourth weekend, the team started Atlantic Coast Conference play with a three-game series at #8 NC State.
Sophomore catcher Garrett Boulware hit two home runs in the game, while batting sixth in the lineup.
Boulware had begun the season batting ninth, but because of strong performances was moved to the cleanup spot by the end of the series.
Starter Schmidt pitched only 3.2 innings, and senior right-hander Jonathan Meyer gave up two runs in relief.
[47] Through the end of the NC State series, Clemson's starting pitching had been strong– each of the team's three weekend starters (Gossett, Schmidt, and Firth) had an earned run average of less than 2.00.
Boulware, who had a triple, home run, and three RBI, scored Thomas Brittle with a walk-off single in the bottom of the ninth.
The Tigers won the first game, 10–5; Boulware hit his fourth home run and had four RBI, and Mike Kent threw three scoreless innings of relief to get his first win.
In game two, Clemson won, 5–2; first baseman Jon McGibbon had three RBI, and senior reliever Jonathan Meyer pitched four scoreless innings to earn his first win.
Duke won the series's final game, 13–1, after starter Firth and reliever Campbell combined to give up 11 earned runs in 3.2 innings.
Georgia scored two runs in the first off of freshman starter Brody Koerner (in his second start of the season) and led for the entire game.
Losing 3–1 after five innings, Clemson took a 4–3 lead in the sixth after Brittle hit a two-RBI single and Tyler Krieger scored on a wild pitch.
The game was still tied, 4–4, into the top of the eleventh inning, when an RBI groundout by Boulware scored Jay Baum.
[66][67][68][69][70] At the end of the North Carolina series, Clemson was 17–11 (6–6 ACC), after going 11–9 in March and splitting the two games completed on April 1.
McGibbon drove in the game's only run in the sixth, and Crownover and Campbell combined to hold Boston College scoreless.