Both teams would meet again in the 2022 AL Wild Card Series, which was won by Cleveland in a two-game sweep.

When the series moved to Tampa, the Rays got on the board with a 5–4 victory in Game 3, thanks to home runs from Evan Longoria and José Lobatón.

Craig Breslow and Koji Uehara held the Rays offense to one run in Game 4 as the Red Sox closed out the series to advance.

The Tigers overcame a 2–1 series deficit to defeat the Athletics in five games once again, and returned to the ALCS for the third year in a row.

Game 2 remained scoreless until the bottom of the ninth when Oakland's Stephen Vogt drove in Yoenis Céspedes with a walk-off base hit single to even the series headed to Detroit.

The Athletics scored six runs off 2013 AL ERA leader Aníbal Sánchez to go up 2–1 in the series, and were one win away from returning to the ALCS.

Coco Crisp regained the lead for the Athletics in the top of the seventh by driving in Stephen Vogt with an RBI single.

In the bottom of the inning, Austin Jackson put the Tigers in the lead for good with a broken-bat RBI single, which scored Andy Dirks.

The Tigers scored three more runs in the bottom of the eighth, and then held off a late rally by the Athletics to force a series-deciding Game 5 in Oakland.

Gerrit Cole pitched six solid innings in Game 2 as the Pirates blew out the Cardinals to even the series headed to Pittsburgh.

The Cardinals would win the series in Game 5 as Adam Wainwright held the Pirates to one run scored.

The Red Sox defeated the Tigers in six games to return to the World Series for the first time since 2007 (in the process denying a rematch of the 2006 World Series between the Cardinals and Tigers), capped off by two Grand Slams by David Ortiz and Shane Victorino in Games 2 and 6 respectively.

In Boston, the Tigers took Game 1 in a 1–0 shutout despite having a no-hit bid broken up in the bottom of the ninth inning.

In Game 5, the Red Sox fended off a late Tigers rally to win 4–3, and regain the series lead headed back to Boston.

In Game 6, the Tigers held a 2–1 lead going into the bottom of the seventh until the Red Sox again loaded the bases.

Then, Shane Victorino hit a grand slam to put the Red Sox in the lead for good, securing the pennant.

The Red Sox would win their next and most recent AL pennant in 2018, against the Houston Astros in five games en route to another World Series title.

The Dodgers prevailed in Game 5 by two runs thanks to a solid pitching performance from Zack Greinke to send the series back to St. Louis.

The Dodgers returned to the NLCS in 2016, but lost to the eventual World Series champion Chicago Cubs in six games.

The Red Sox defeated the Cardinals in six games to win their eighth World Series title in franchise history.

It marked the first time that the Red Sox had won the World Series at home since 1918, which is, ironically, the year when the Curse of the Bambino started.