Rafael Nadal defeated Novak Djokovic in the final, 6–2, 3–6, 6–4, 6–1 to win the men's singles tennis title at the 2013 US Open.

[1] This marked the third time in four years (following 2010 and 2011) that Nadal and Djokovic contested the final.

Andy Murray was the defending champion, but lost in the quarterfinals to Stanislas Wawrinka.

[3] Roger Federer's streak of nine consecutive US Open quarterfinals ended when he lost to Tommy Robredo in the fourth round.

Federer matched Wayne Ferreira's all-time record of 56 consecutive major main draw appearances.