The 2013 Winston-Salem Open was a men's tennis tournament played on outdoor hard courts.

It was the 45th edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and was part of the ATP World Tour 250 Series of the 2013 ATP World Tour.

Ninth-seeded Jürgen Melzer won the singles title.

[1] The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following pairs received wildcards into the doubles main draw: The following pair received entry as alternates: Jürgen Melzer def.

Daniel Nestor / Leander Paes def.